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According to a position paper by the American Association of Maxillofacial Surgeons (AAOMS), MRONJ has been associated with bisphosphonates and other antiresorptive agents (denosumab), and antiangiogenic agents (eg, bevacizumab, sunitinib) used for the treatment of osteoporosis or malignancy; risk is significantly higher in cancer patients receiving antiresorptive therapy compared to patients receiving osteoporosis treatment (regardless of medication used or dosing schedule).
Adverse events were recorded and coded with the use of the Medical Dictionary for Regulatory Activities system.
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Factors that were not significantly associated with the risk of hip fracture included hair color, ethnic ancestry, whether there was a maternal history of fractures other than hip fracture, the number of children breast-fed, the timing of menopause, past smoking status, whether the subject had cataracts, and whether she had used short-acting benzodiazepines ( Table 4 Factors Not Significantly Associated with Hip Fracture in Age-Adjusted Models.
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In 2010, the American Society of Bone and Mineral Research Femoral Fracture Task Force recommended that US health regulators rewrite the warning labels for bisphosphonates because of their possible association with atypical femur fractures.
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Very few children are at present being prescribed bisphosphonates and there is currently a paucity of evidence from human or animal studies regarding the risk of BONJ in children or adolescents.
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