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These situations can lead to severe dehydration, and it may be necessary to stop taking GLUCOVANCE temporarily.

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Take glyburide and metformin with meals.

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WARNING: A small number of people who have taken metformin hydrochloride have developed a serious condition called lactic acidosis.

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Wherever χ 2-test was not valid, Fischer's exact test was used and 2-tailed P-value was calculated.

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Possible side effects include stomach problems, low blood sugar, and allergic skin reactions.

Also, GLUCOVANCE therapy resulted in greater reduction in FPG compared to glyburide, metformin, or placebo, but the differences from glyburide and metformin did not reach statistical significance.

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GLUCOVANCE should be given with meals and should be initiated at a low dose, with gradual dose escalation as described below, in order to avoid hypoglycemia (largely due to glyburide), to reduce GI side effects (largely due to metformin), and to permit determination of the minimum effective dose for adequate control of blood glucose for the individual patient.

When such drugs are withdrawn from a patient receiving glyburide tablets, the patient should be observed closely for hypoglycemia.

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In controlled clinical trials with metformin of 29 weeks duration, a decrease to subnormal levels of previously normal serum vitamin B 12, without clinical manifestations, was observed in approximately 7% of patients.

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Some MEDICINES MAY INTERACT with glyburide.

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Glyburide provides approximately the same degree of blood glucose control as 250 to 375 mg chlorpropamide, 250 to 375 mg tolazamide, 500 to 750 mg acetohexamide, or 1000 to 1500 mg tolbutamide.

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We found that glyburide was as effective as insulin in producing glycemic control, and few women assigned to glyburide had to be switched to insulin.

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