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Do Not use clarithromycin if your child is known to be allergic to this or to any similar antibiotics such as azithromycin or erythromcyin.

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Secondary outcomes were all cause, cardiac, or non-cardiac mortality, arrhythmia, and stroke.

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Restrepo and associates () found a survival benefit of macrolide therapy in 30- and 90-day mortality rates for patients with sepsis after pneumonia.

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Objective To study the association of clarithromycin with cardiovascular events in the setting of acute exacerbations of chronic obstructive pulmonary disease and community acquired pneumonia.

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In Iran, the clarithromycin resistance rate is already 17% even though this drug has not been introduced in this country but erythromycin is used.

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Because 14-OH-Clarithromycin has reduced activity against Mycobacterium avium complex (MAC), overall activity against this pathogen may be altered; therefore alternatives to Clarithromycin should be considered for the treatment of MAC.

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Discontinuation due to adverse reactions occurred in 18% of patients receiving BIAXIN compared to 17% of patients receiving placebo in this trial.

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The most common side effects reported are stomach and intestinal problems, an abnormal taste in the mouth and headaches.

In some cases, clarithromycin was administered concomitantly with other drugs known to be associated with rhabdomyolysis (such as statins, fibrates, colchicine or allopurinol).

CLARICOR (Effect of Clarithromycin on Mortality and Morbidity in Patients with Ischemic Heart Disease trial) was a double blind, placebo controlled trial showing that a two week course of clarithromycin significantly increased cardiovascular and all cause mortality in patients with coronary heart disease but no evidence of respiratory infection.

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There is resistance to macrolides in certain bacterial infections caused by Streptococcus pneumoniae and Staphylococcus aureus.

The renal clearance of clarithromycin approximates the normal glomerular filtration rate.

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The increase relates to improved microbiologic techniques for isolating NTM from clinical specimens and, more importantly, to advances in molecular techniques with the development and acceptance of 16S rRNA gene sequencing as a standard for defining new species.

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Similar effects were reported in another study, along with inhibition of IL-8 levels in nasal lavage fluid, which was thought to drive polyp growth ().

The major metabolite found in urine is 14-OH clarithromycin, which accounts for an additional 10% to 15% of the dose with a 500 mg tablet administered every 12 hours.

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However, there appears to be no significant effect of macrolides on chloride transport in persons with cystic fibrosis (CF).

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This remedy is supposed to cures colds that are already in progress - causing the symptoms to begin to clear up within a few hours.

Knowledge in these areas is gradually emerging, however, and enough has been learned to begin a realistic discussion of NTM disease prevention.

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In the event of severe acute hypersensitivity reactions, such as anaphylaxis, Stevens-Johnson syndrome, toxic epidermal necrolysis, drug rash with eosinophilia and systemic symptoms (DRESS), and Henoch-Schonlein purpura clarithromycin therapy should be discontinued immediately and appropriate treatment should be urgently initiated.

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Use each of these medications as recommended by your healthcare provider, or according to the instructions provided.

Clarithromycin belongs to a group of medications known as macrolides.

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