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IP with immunoblots for SHP2, p110, GAB2 and p85 in BCR-ABL positive H929 cells after treatment with either DMSO vehicle or several kinase inhibitors (GSK11220212 (ERK inhibitor), NVP-AEW541 (IGF1R inhibitor), BKM120 (pan PI3K inhibitor), imatinib (ABL, PDGFR inhibitor)) to test the effect on the SHP2-p85 complex when either ERK or AKT signaling was inhibited.

It was not administered to the remaining 38 patients because the use of EGFR inhibitor was not available before June 2002 in Japan.

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Afatinib versus cisplatin-based chemotherapy for EGFR mutation-positive lung adenocarcinoma (LUX-Lung 3 and LUX-Lung 6): analysis of overall survival data from two randomised, phase 3 trials.

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The names of the targeted therapy types listed below are links to lists of ongoing clinical trials that are testing those types of targeted therapies in cancer patients.

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